Evonik solutions for pharmaceutical solid dosage forms in pharmaceutical formulations
- Anti-caking and free flow
- Glidant
- Mechanical tablet stability
- Surface effect in emulsions
- Carrier for liquid active ingredients
- Process aid for 3D printing of tablets
Evonik’s pharma grade silica and silicates AEROSIL®, AEROPERL®, ZEOPHARM® and RXCIPIENTS® FM 1000 help the pharmaceutical industry with many different formulation challenges for solid dosage forms such as tablets, capsules, and sachets.
AEROSIL® Pharma: the industry standard glidant
AEROSIL® Pharma is the industry standard glidant. As an anti-caking and free-flow agent, it makes processing all kinds of powdered products or mixtures in tableting equipment easier and increases production throughput. High-speed tablet presses require optimal powder flow from the mixer to the tableting machine. It is essential for continuous and sustainable manufacturing. AEROSIL® Pharma also improves resistance to mechanical stresses in the manufacturing process. Another important effect of silica as a pharmaceutical excipient is precise dosing and homogeneous distribution of active ingredients (APIs) in each tablet or capsule.
As a mesoporous carrier, AEROPERL® Pharma is used to incorporate liquids and solutions with micronized solids, improving the dissolution of poorly soluble APIs.
All in all, AEROSIL® and AEROPERL® Pharma colloidal silicon dioxide contributes to increased productivity with consistent product quality.
RXCIPIENTS® FM 1000 for orally disintegrating tablets
Orally disintegrating tablets (ODTs) provide convenient and immediate help for patients with difficulty swallowing pills, since they dissolve in the mouth within seconds. Being so brittle and sensitive to moisture, however, ODTs pose major challenges in formulation and handling. RXCIPIENTS® FM 1000 calcium silicate is utilized for orally disintegrating tablets (ODTs) and, when formulated with a co-disintegrant, allows for rapid disintegration in the stomach to deliver APIs more rapidly. RXCIPIENTS® FM 1000 has a friability of less than 1%. As a result, tablets do not require any special packaging. They can be packaged in bulk or HDPE bottles. The stronger tablets also enable manufacturers to produce ODT tablets in house with existing tableting equipment.
ZEOPHARM® calcium silicates: A versatile pharmaceutical excipient
ZEOPHARM® synthetic amorphous calcium silicate NF products are highly absorptive materials that can be utilized for multiple purposes in tableting and bulk powders. They function as a glidant to allow free flow into the tablet press, reducing both tablet weight variation and moisture absorption. ZEOPHARM® calcium silicates can help to balance optimum stability with high dissolving ability, thus improving sensory properties and avoiding a dry mouth feel. As a highly porous product, ZEOPHARM® calcium silicate can also be used to convert liquid active ingredients (API) into free-flowing powders and can load up to 75% liquid by weight.
Safety and quality according to GMP guidelines
AEROSIL® and AEROPERL® fumed silica products identified by the suffix “Pharma” and ZEOPHARM® and RXCIPIENTS® FM 1000 are manufactured according to the International Pharmaceutical Excipients Council (IPEC) GMP guidelines for pharmaceutical excipients. Full traceability of all raw materials and production conditions and stringent observance of hygiene protocols during bag filling are guaranteed. The dedicated products come with testing for several pharmaceutical monographs, ensuring consistent high quality for your drug manufacturing.